FUM1 (YPL262W, P08417) notes

• Single fumarase gene; mitochondrial and cytosolic forms from one gene PMID:3040736.
• Single translation product, MPP-processed, distributed between cytosol and mitochondria PMID:11585823.
• fum1 mutant excretes fumarate PMID:1587456.
• Cytosolic pool recruited to nucleus after DSBs; activity-dependent [PMID:20231875 "recruited from the cytosol to the nucleus upon DNA damage induction"; "This function of fumarase depends on its enzymatic activity"].

Curation: protein binding rows removed (policy). Core: TCA fumarase (matrix) + DSB-repair role of cytosolic/nuclear pool.

Description follow-up (SGD text)

• SGD says Fum1 is "phosphorylated in mitochondria". UniProt records a phosphothreonine at residue 428 from a large-scale mitochondrial phosphoproteome [file:yeast/FUM1/FUM1-uniprot.txt "/note=\"Phosphothreonine\""; evidence ECO:0007744|PubMed:17761666]. PMID:17761666 (Reinders et al. 2007, abstract only) analysed highly purified mitochondria PMID:17761666; the abstract does not name Fum1. No functional consequence is known, so this is noted as peripheral and not added to the description or annotations.