Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Combined Automated Annotation using Multiple IEA Methods

Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities.

Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.

A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.

The crystal structure of human CDK7 and its protein recognition properties.

Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.

DNA-Bound peptides control the mRNA transcription through CDK7.

Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

TFIIH: when transcription met DNA repair.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration.

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

The protein interaction landscape of the human CMGC kinase group.

A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing.

Architecture of the human interactome defines protein communities and disease networks.

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Cdk-activating kinase complex is a component of human transcription factor TFIIH.

Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase.

Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.

Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.

Regulation of CAK kinase activity by p53.

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

Formation of the closed pre-initiation complex

Addition of nucleotides between position +11 and +30

Recruitment of elongation factors to form elongation complex

Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Addition of nucleotides leads to transcript elongation

Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex

CAK phosphorylates CDK1 bound to CCNB1

CAK phosphorylates CDK1 bound to CCNA

CAK-mediated phosphorylation of Cyclin A:Cdk2

CAK-mediated phosphorylation of Cyclin E:Cdk2

Recruitment of XPA and release of CAK

TFIIH binds GG-NER site to form a verification complex

RNA Pol II initiates transcription from damaged DNA template

Active RNA Pol II complex transcribes lesion-containing DNA template

ERCC8 (CSA) binds stalled RNA Pol II

ERCC6 binds stalled RNA Pol II

ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II

Assembly of the pre-incision complex in TC-NER

UVSSA:USP7 deubiquitinates ERCC6

ERCC2-facilitated RNA Pol II backtracking in TC-NER

ERCC5 and RPA bind TC-NER site

Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER

5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER

DNA polymerases delta, epsilon or kappa bind the TC-NER site

3' incision by ERCC5 (XPG) in TC-NER

Ligation of newly synthesized repair patch to incised DNA in TC-NER

Recovery of RNA synthesis after TC-NER

CDK12 phosphorylates RNA Pol II CTD at DNA repair genes

CCNK:CDK12 binds RNA Pol II at DNA repair genes

RNA polymerase II transcribes snRNA genes

CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter

General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain

RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

Pre-snRNA transcript initiation, Integrator binding, LEC binding

Integrator complex processes the 3' end of snRNA

Pre-snRNA is elongated and capped with 7-methylguanosine

CBCAP complex binds 7-methylguanosine cap of snRNA

Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter

Loss of Rrn3 from RNA Polymerase I promoter escape complex

RNA Polymerase II Transcription

Abortive initiation after formation of the first phosphodiester bond

Elongation of pre-rRNA transcript

Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box

PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box

Addition of the third nucleotide on the nascent transcript

Abortive Initiation Before Second Transition

NTP Binds Active Site of RNA Polymerase II

Fall Back to Closed Pre-initiation Complex

Newly Formed Phosphodiester Bond Stabilized and PPi Released

Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

Addition of the fourth nucleotide on the Nascent Transcript: Second Transition

Addition of Nucleotides 5 through 9 on the growing Transcript

Abortive Initiation After Second Transition

RNA Polymerase II Promoter Opening: First Transition

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition

Activation of GT

RNA Polymerase II CTD (phosphorylated) binds to CE

Phosphorylation (Ser5) of RNA pol II CTD

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

Capping complex formation

Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme

Formation of the CE:GMP intermediate complex

Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA

Dissociation of transcript with 5'-GMP from GT

Methylation of GMP-cap by RNA Methyltransferase

CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6

Unwinding of DNA for the Nascent Transcript: Second Transition

Unwinding DNA for the nascent transcript

ERCC3-facilitated RNA Pol II backtracking in TC-NER

UniProt record for human CDK7