Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae.
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor.
Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells.
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Stimulation by toll-like receptors inhibits osteoclast differentiation.
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved.
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness.
Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria.
Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs.
TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.
A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression.
Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome.
The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes.
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.
Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7.
Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells.
Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.
Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells.
MAPPIT analysis of TLR adaptor complexes.
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.
Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin.
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9.
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.
MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4.
Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells.
TREM-1 interaction with the LPS/TLR4 receptor complex.
TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2.
Isolated Toll-like receptor transmembrane domains are capable of oligomerization.
Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.
Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.
Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress.
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
MiR-6835 promoted LPS-induced inflammation of HUVECs associated with the interaction between TLR-4 and AdipoR1 in lipid rafts.
Reduced peripheral blood miR-140 may be a biomarker for acute lung injury by targeting Toll-like receptor 4 (TLR4).
Differentiation expression of toll-like receptor4 (TLR4) caused by the dysregulation of microRNA-140-5p is responsible for the development of postoperation infection.
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway.
Structural and functional understanding of the toll-like receptors.
PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway.
Recombinant human KAI1/CD82 attenuates M1 macrophage polarization on LPS-stimulated RAW264.7 cells via blocking TLR4/JNK/NF-κB signal pathway.
Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB.
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
Transfer of LPS onto TLR4
MyD88 forms a complex with TIRAP:activated TLR2/4
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2)
TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Multiple IRAK1 autophosphorylation steps
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
TRIF:activated TLR3/TLR4 complex recruits RIP1
Endocytosis of TLR4:LY96:LPS:CD14
Activated TLR2/4 interacts with MAL (TIRAP)
TIRAP is phosphorylated by BTK
TRAF3 binds TICAM1:activated TLR4 complex
Auto-ubiquitination of TRAF3
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Activated TLR2/4:TIRAP interacts with BTK
SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14
TLR4-induced ripoptosome assembly
Caspase-8 processing within TLR4 complex
RIP3 binds TRIF to mediate necroptosis
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
S100A8:S100A9 binds TLR4:LY96
SFTPA/SFTPD binds TLR4:LY96
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4
Defective MyD88 does not oligomerize within the activated TLR2/4 complex
Defective MyD88 does not bind MAL(TIRAP):TLR2/4
oxLDL:CD36 binds TLR4:TLR6
Cleaved fibrinogen products bind TLR4:LY96
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
Activation of TAK1 complex bound to activated TLR4 complex
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
Activated TLR4:TICAM1 recruits TRAF6
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
IKBKG subunit of IKK complex binds polyubiquinated RIP1
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
Phosphorylated TAK1 leaves activated TLR receptor complex
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
Hemes:LY96 activates TLR4
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
TBK1 is phosphorylated within the activated TLR4 complex
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
OPTN binds TBK1 within the activated TLR4 complex
IKKε (IKBKE) is ubiquitinated within the activated TLR4
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex
RSV F binds TLR4:LY96:CD14
Falcon deep research report on TLR4