Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
-
SCAMP3 identified in B-cell exosome proteome
"We first analyzed the total proteome of highly purified B cell-derived exosomes using sensitive and accurate mass spectrometry (MS), and identified 539 proteins"
The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions.
-
SCAMP3 characterized as member of SCAMP family
"Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions"
-
SCAMPs colocalize and function in post-Golgi recycling pathways
"These findings suggest that the SCAMPs may largely function at the same sites during vesicular transport rather than in separate post-Golgi recycling pathways"
SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.
-
SCAMP3 contains PPAY motif binding NEDD4 family E3 ligases
"SCAMP3 is multimonoubiquitylated and is able to associate with Nedd4 HECT ubiquitin ligases and the ESCRT-I subunit Tsg101 via its PY and PSAP motifs, respectively"
-
SCAMP3 is multi-monoubiquitinated
"SCAMP3 is multimonoubiquitylated"
-
SCAMP3 promotes EGFR recycling over degradation
"Depletion of SCAMP3 in HeLa cells by inhibitory RNA accelerated degradation of EGFR and EGF while inhibiting recycling"
-
SCAMP3 interacts with NEDD4, NEDD4L, and TSG101
"SCAMP3 is multimonoubiquitylated and is able to associate with Nedd4 HECT ubiquitin ligases and the ESCRT-I subunit Tsg101 via its PY and PSAP motifs, respectively"
Deep research on SCAMP3 function