Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

UniProtKB O00522: human KRIT1 sequence and curated functions

UniProtKB A0A9L0SR44: horse KRIT1 sequence and domains

A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1.

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.

CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

KRIT1 regulates the homeostasis of intracellular reactive oxygen species.