Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.
-
Human IRF9 loss of function abolishes ISGF3 formation, ISRE binding and ISRE-driven transcription in response to IFN-alpha2b, and is rescued by wild-type IRF9.
"These phenotypes are rescued by wild-type IRF9"
Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation.
Impaired control of multiple viral infections in a family with complete IRF9 deficiency.
UniProt record for donkey IRF9 (A0A9L0I7X9)
UniProt Swiss-Prot record for human IRF9 (Q00978)
IRF9: donkey-human sequence comparison
-
Donkey IRF9 is 80% identical to human over 388 paired residues and has a C-terminal extension.
"The donkey sequence A0A9L0I7X9 (421 residues) aligns to human Q00978 (393 residues) with 80.41% identity across 388 paired residues."
IRF9 DNA-binding domain check