The raw UniProt gene name is trkA; ktrA is the experimental literature name for SAUSA300_0988. No protein pore activity is assigned. The two original transport-process rows are refined to regulation of potassium transport, while the incorrect independent transporter MF is refined to regulator activity.
Falcon deep research was attempted using just deep-research-falcon STAA3 ktrA and failed with HTTP 403 authentication failure. This is manual primary-source research, not a provider-generated report. The original machine annotation payloads and raw UniProt/GOA files are retained. No NEW annotation rows were added in the initial pass; the follow-up below records the final recommendation.
Module membership: MODULE:bacterial_c_di_amp_signaling, receptor arm. No unsupported top-level association slot is used.
The process actions refine direct regulator roles to regulation of potassium transport; membrane translocation remains the partner activity.
Added NEW GO:0180001 (IDA; PMID:23671116) for the directly measured RCK_C ligand-binding activity. The primary study identifies SAUSA300_0988 from the USA300 LAC* strain.
Retained GO:0015459 potassium channel regulator activity after checking the QuickGO definition: “Binds to and modulates the activity of a potassium channel.” The broader GO:0141108 transporter regulator activity covers modulation of a transporter. The target-specific primary study in USA300 LAC calls this a system with “one regulatory protein and two ion-conducting channels” and concludes that KtrA regulates KtrB/KtrD (PMID:23815639(https://pubmed.ncbi.nlm.nih.gov/23815639/), full text fetched). This supports the more specific existing term, while preserving the distinction between regulator and conducting subunit. CabP's inspected study establishes interaction with SPD_0076 and uptake modulation; its broader term reflects that evidence. KhtT regulates a cation/proton antiporter, so it is not an equivalent channel-regulator comparator.