Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Dissection of epistasis in oligogenic Bardet-Biedl syndrome.
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.
A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.
BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.
Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation.
Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome.
The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.
Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.
A proteome-scale map of the human interactome network.
Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Protein interaction perturbation profiling at amino-acid resolution.
Dlec1 is required for spermatogenesis and male fertility in mice.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
ARL6:GTP and the BBSome bind ciliary cargo
ARL6:GTP and the BBSome target cargo to the primary cilium
LZTFL1 binds the BBSome and prevents its traffic to the cilium
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function.
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Functional modelling of a novel mutation in BBS5.
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Zebrafish bbs5 morpholino perturbation produced abnormal heart looping, retinal layering and pronephric phenotypes. Wild-type and c.966dupT mRNAs differed in their ability to rescue the tested composite and organ phenotypes.
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Tagged wild-type BBS5 colocalized with pericentrin in HEK293 cells, whereas the tested mutant had diffuse localization. This does not establish every endogenous compartment or autonomous transport activity.
Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy.
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Mouse rod-cilium STORM imaging detected BBS5 near basal bodies/pericentriolar material, along the outer-segment axoneme and in connecting-cilium clusters. Some clusters colocalized with IFT88; others did not.
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In Bbs2-, Bbs4- and Bbs7-deficient rods, BBS5 localization within the connecting cilium was largely retained despite other abnormalities. These comparisons should not be presented as Bbs5 perturbation phenotypes.
Structure of the human BBSome core complex.