MAML1 notes

Falcon integration, 2026-05-12

• Falcon supports MAML1 as a nuclear transcriptional coactivator in the Notch intracellular domain-RBPJ/CSL activation complex, with direct HES1 transcriptional activation evidence PMID:11101851.
• The review should prefer Notch target-gene transcription terms over a broad pathway-only framing: [file:human/MAML1/MAML1-deep-research-falcon.md "Prefer “Notch target gene transcription” over broad “Notch signaling pathway” unless direct pathway-level phenotypes are tied specifically to human MAML1 (not dnMAML pan-inhibition, not paralog redundancy)."].
• Generic protein binding rows are less informative than the specific coactivator, complex-membership, and CDK8-binding evidence. CDK8 binding is supported directly PMID:15546612.
• The PMID:17317671 peptide antigen binding annotation appears erroneous: the paper supports p53 coactivator activity, not antigen binding PMID:17317671.
• Nuclear/nucleoplasm localization is solid as context, but nuclear speck or nuclear-body assignments should be conservative because Falcon notes that the evidence is often overexpression-linked [file:human/MAML1/MAML1-deep-research-falcon.md "Nuclear bodies/specks: nuclear-body localization is supported but is often overexpression-linked; annotate cautiously at specific subnuclear compartments."].