GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

High-confidence human mitochondrial proteome.

"We classified >8,000 proteins in mitochondrial preparations of human cells and defined a mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP)."

PMID:22569362

The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.

The Armcx family is mitochondrial and derived from Armc10.

"Here we show a new protein family that localizes to the mitochondria and controls mitochondrial dynamics."

PMID:19304657

The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.

ARMCX3 is an integral mitochondrial outer-membrane protein.

"Biochemical analyses indicate that ARMCX3 is an integral membrane protein of the mitochondrial outer membrane."

PMID:11162520

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

ALEX2 transcripts are broadly expressed.

"ALEX1 and ALEX2 transcripts are found in all human tissues examined except peripheral blood leukocytes."

PMID:22249249

Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.

ARMCX2 acquires promoter methylation in chemoresistant ovarian cancer.

"Furthermore, 5/13 genes (ARMCX2, COL1A1, MDK, MEST and MLH1) acquired methylation in drug-resistant ovarian cancer-sustaining (side population) cells."

PMID:33267763

GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners.

file:human/ARMCX2/ARMCX2-uniprot.txt

UniProt entry Q7L311 (ARMX2_HUMAN)

file:human/ARMCX2/ARMCX2-deep-research-affinage.md

Affinage mechanistic annotation for ARMCX2 (human)