Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs using Ensembl Compara
Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of UniProtKB keywords with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.
A protein interaction framework for human mRNA degradation.
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.
Human INT6/eIF3e is required for nonsense-mediated mRNA decay.
Results of the determination of serum markers in patients with malignant melanoma.
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
A UPF3-mediated regulatory switch that maintains RNA surveillance.
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.
The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Nonsense-mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)
Reactome: nonsense-mediated decay (cytosol)