Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction.

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein.

Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum.

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.

Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.

Subproteomic study of hepatitis C virus replicon reveals Ras-GTPase-activating protein binding protein 1 as potential HCV RC component.

Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation.

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.

Human VAP-C negatively regulates hepatitis C virus propagation.

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.

Defining the human deubiquitinating enzyme interaction landscape.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.

A directed protein interaction network for investigating intracellular signal transduction.

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.

The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.

MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.

Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.

STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.

A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.

Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.

Widespread macromolecular interaction perturbations in human genetic disorders.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.

The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1.

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.

A reference map of the human binary protein interactome.

GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution.

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Physical and functional interactome atlas of human receptor tyrosine kinases.

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

The ORP9-ORP11 dimer promotes sphingomyelin synthesis.

Multimodal cell maps as a foundation for structural and functional genomics.

STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch.

Glycolipid transfer protein modulates vesicular trafficking from the endoplasmic reticulum in HeLa cells.

Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.

Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.

PPM1L dephosphorylates multiphospho-CERT1-2

Exocytosis of azurophil granule membrane proteins

SGTA binds Tail-anchored protein

CERT1-2 transfers CERA from the ER membrane to the Golgi membrane

UniProtKB Q9P0L0: human VAPA curated sequence and functional features