Mef2 (Drosophila melanogaster, P40791) - curation notes

Automated deep research failed for this run (falcon 402, OpenAI 401); notes from cached publications.

Function

• MADS-box TF; MADS mutants lose DNA binding and are lethal PMID:12366381.
• Direct targets: sing PMID:25797154; miR-92b PMID:22899845; actin and muscle genes with CF2 PMID:18160709.

Development

• Required for differentiation, not specification, of all muscle types PMID:7839146; cardial cells lack MHC PMID:7729689.
• Direct Tinman target in heart PMID:9034334.
• Adult myoblast fusion PMID:22008792.

Non-muscle roles

• Clock neurons PMID:20427646.
• Fat body immune-metabolic switch, TBP partner PMID:24075010.

Review decisions

• protein binding (TBP) -> MODIFY GO:0017025 TBP-class protein binding.
• GO:0032968 elongation and GO:0010468 -> MODIFY GO:0045944.
• NEW GO:0055007 cardiac muscle cell differentiation (module annoton process; absent from GOA).
• PMID:25747460 (troponin-I cis mutation) abstract does not mention Mef2; accepted deferring to curator.