Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Proteomic characterization of the human centrosome by protein correlation profiling.

Defining the membrane proteome of NK cells.

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.

AJUBA facilitates AURKA autophosphorylation

AJUBA binds centrosome-associated AURKA

AURKA phosphorylates PLK1

BORA binds PLK1 and AURKA

Plk1-mediated phosphorylation of Nlp

Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome

Loss of C-Nap-1 from centrosomes

Dissociation of Phospho-Nlp from the centrosome

Recruitment of Plk1 to centrosomes

Association of NuMA with microtubules

Recruitment of CDK11p58 to the centrosomes

Translocation of NuMA to the centrosomes

RAB3IP stimulates nucleotide exchange on RAB8A

C2CD3 binds the mother centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

CP110 and CEP97 dissociate from the centriole

The distal appendage proteins recruit TTBK2

Recruitment of transition zone proteins

MARK4 binds ODF2 in the centriole

CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body

TPX2 binds AURKA at centrosomes

TPX2 promotes AURKA autophosphorylation

CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation.

CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation.

In situ cryo-electron tomography reveals the progressive biogenesis of basal bodies and cilia in mouse ependymal cells.