GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

PMID:11967071

Over 1000 genes are involved in the DNA damage response of Escherichia coli.

Nearly 30% of E. coli genes change expression after mitomycin C treatment.

"a large number of genes (nearly 30% of all genes) displayed significant changes in their expression level"

PMID:16766528

A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes.

Defines the anSME family from a Firmicutes Cys-type sulfatase-maturating enzyme.

"This finding leads to the definition of a new enzyme family of sulfatase-maturating enzymes that we have named anSME"

PMID:17303125

First evidences for a third sulfatase maturation system in prokaryotes from E. coli aslB and ydeM deletion mutants.

Deleting ydeM, aslB and yidF in E. coli K-12 does not impair maturation of heterologous Cys-type sulfatases, which occurs only aerobically.

"knocking-out of aslB, ydeM and yidF does not impair Cys-type sulfatase maturation"

PMID:14749327

Post-translational formylglycine modification of bacterial sulfatases by the radical S-adenosylmethionine protein AtsB.

The Ser-type anSME AtsB of Klebsiella oxidises sulfatase serine to formylglycine by radical SAM chemistry.

"AtsB oxidizes serine to FGly by a radical mechanism that is initiated through reductive cleavage of SAM"

file:ECOLI/ydeM/ydeM-uniprot.txt

UniProtKB entry P76134 (YDEM_ECOLI)

file:ECOLI/aslB/aslB-bioinformatics/RESULTS.md

AslB and YdeM vs characterised anaerobic sulfatase-maturating enzymes

YdeM keeps all cluster-ligand cysteines, SAM-contact residues and the catalytic aspartate of the C. perfringens anSME.

"YdeM keeps all 17 reference features: 11 cluster cysteines"