LYS5 (YGL154C, P50113) notes

Pathway context: activates Lys2 (not a YeastCyc pathway gene); 4'-phosphopantetheinyl transferase (EC 2.7.8.7).

• Activity: PMID:10320345. GO:0008897 definition explicitly includes PCP and cites PMID:10320345.
• Genetics: PMID:3921525.
• NEW: GO:0018215 protein phosphopantetheinylation (IDA PMID:10320345). Comparator: QuickGO shows GO:0018215 on C. albicans LYS5 (Q59N08, CGD IDA/IGI) and Arabidopsis PPT (TAIR IDA). Lys5 itself performs the modification, so it passes the participation test.
• All existing annotations accepted; Mg2+ binding non-core.

2026-11-06 PTHR12215 audit

Rechecked LYS5 against the local PTHR12215 PAINT slice. PTN000259224 still supports cytosol, holo-[acyl-carrier-protein] synthase activity, and protein maturation, while the fungal PTN000954835 node supports L-lysine biosynthesis. The legacy GO:0005737 cytoplasm TAS row should be narrowed to GO:0005829 cytosol; the SGD IMP row and fungal PAINT IBA justify listing L-lysine biosynthesis as a directly involved core process alongside protein phosphopantetheinylation.