Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry P04075 (ALDOA_HUMAN), fructose-bisphosphate aldolase A
Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications.
Aldolase binding to actin-containing filaments. Formation of paracrystals.
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr).
Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function.
A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein.
Exosomes with immune modulatory features are present in human breast milk.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer.
Proteomic characterization of the human sperm nucleus.
Toward an understanding of the protein interaction network of the human liver.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Identification of sperm head proteins involved in zona pellucida binding.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.
Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.
Mode of interactions of human aldolase isozymes with cytoskeletons.
Exocytosis of platelet alpha granule contents
Exocytosis of tertiary granule lumen proteins
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
Aldolase tetramers convert GA3P and DHAP to F1,6PP
Aldolase tetramer cleaves F1,6PP