The PA3177 Gene Encodes an Active Diguanylate Cyclase That Contributes to Biofilm Antimicrobial Tolerance but Not Biofilm Formation by Pseudomonas aeruginosa.
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Deletion lowers biofilm c-di-GMP 5-fold; the GGAAF active-site mutant fails to restore it.
"Inactivation of PA3177 reduced total cellular c-di-GMP levels 5-fold under biofilm growth conditions"
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PA3177 is not needed for attachment or biofilm formation.
"While PA3177 contributed to biofilm drug tolerance, inactivation of PA3177 had no effect on attachment and biofilm formation."
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt