Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The human DNA ligase III gene encodes nuclear and mitochondrial proteins.
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.
Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.
Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair.
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.
Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells.
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
XRCC1 - Strategies for coordinating and assembling a versatile DNA damage response.
Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB
Dissociation of LIG3:XRCC1 complex from the BER site
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution
LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA
LIG3 ligates NEIL1,NEIL2-generated single strand break
MRN recruits LIG3:XRCC1 to MMEJ sites
LIG3 ligates remaining SSBs in MMEJ
Ligation of newly synthesized repair patch to incised DNA in GG-NER
Ligation of newly synthesized repair patch to incised DNA in TC-NER
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway
Resynthesis of excised residue by POLB
LIG3 (Ligase III) ligates nascent mitochondrial DNA strands
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.
DNA ligase III as a candidate component of backup pathways of nonhomologous end joining.
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
UniProt entry P49916 (LIG3_HUMAN)
LIG3 review notes and literature search log