Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:18026101

ATP-sensitive potassium channels mediate survival during infection in mammals and insects.

KATP perturbation increases infection susceptibility in the reported models.

PMID:20610380

Ankyrin-B regulates Kir6.2 membrane expression and function in heart.

SUR2A coassembles with Kir6.2; the paper directly includes SUR2A experiments.

PMID:24439875

ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene.

Human ABCC9 variants alter ATP-dependent KATP current regulation.

PMID:26181369

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity.

Human SUR2A NBD2 has measurable MgATPase activity that differs from SUR1 and changes with site-directed mutation.

PMID:26621776

Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.

Cantú-equivalent SUR2A variants increase channel activity through enhanced MgADP activation or reduced ATP inhibition.

PMID:28842488

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

SUR2A-containing channel controls and Kir6 variants are examined by flux and electrophysiology.

PMID:30280653

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCC9/Kir6.1 are discussed in pericyte ion transport and cerebral blood-flow regulation; this does not directly establish transport across the endothelial barrier.

Reactome:R-HSA-1369017

Activation of ATP sensitive Potassium channels in muscle cells

Reactome:R-HSA-1454916

The ABCC family mediates organic anion transport

Reactome:R-HSA-382556

ABC-family proteins mediated transport

Reactome:R-HSA-5678261

KCNJ11:ABCC9 transports K+ from extracellular region to cytosol

Reactome:R-HSA-5678418

Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol

Reactome:R-HSA-9691566

KCNJ11:ABCC9 binds nicorandil

PMID:15034580

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating.

ABCC9 mutations were reported in dilated cardiomyopathy with altered channel-related nucleotide cycling.

PMID:11934987

Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.

Source for the mouse complex-binding annotation remains unresolved.

PMID:16085792

Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart.

Mouse cardiac channel-subunit expression increases during maturation; precise sarcomere versus membrane-pattern interpretation remains unresolved.

PMID:8630239

A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.

Rat SUR2 confers distinct drug responsiveness on reconstituted Kir6.2 channels.

PMID:18434629

KATP channel subunits are expressed in the epididymal epithelium in several mammalian species.

SUR2 has tissue-dependent intracellular immunostaining as well as expression in epididymal cells and spermatozoa.

PMID:35562524

Structural identification of vasodilator binding sites on the SUR2 subunit.

Nucleotide-bound SUR2 structures locate vasodilator-binding sites and clarify channel regulation.

PMID:18001767

Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity.

Mouse cardiac SUR2 expression supports the sarcolemmal localization context.

PMID:9831708

Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.

Human SUR2A and Kir6.2 reconstitute ATP- and sulfonylurea-sensitive channels matching native sarcolemmal channels.

PMID:37330603

The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix.

SUR2 nucleotide occupancy, R-helix interactions and C-terminal isoform differences regulate channel activation.

PMID:24648545

Abcc9 is required for the transition to oxidative metabolism in the newborn heart.

SUR2 short forms are implicated in cardiac mitochondrial metabolic maturation.

PMID:34711681

Vascular K(ATP) channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.

SUR2B is a nontransporting regulatory subunit arranged around the Kir6.1 potassium-conducting pore.

PMID:22610116

Dominant missense mutations in ABCC9 cause Cantú syndrome.

Dominant ABCC9 variants are associated with Cantú syndrome.

PMID:31575858

ABCC9-related Intellectual disability Myopathy Syndrome is a K(ATP) channelopathy with loss-of-function mutations in ABCC9.

Biallelic ABCC9 loss-of-function causes intellectual disability/myopathy; SUR2 exon8 deletion abolishes functional channel expression in the tested system.

PMID:20935152

The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice.

SUR2 mutant hearts display altered mitochondrial bioenergetic responses.

PMID:19797704

Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing.

Short intra-exonic SUR2 splice products support a mitochondrial context distinct from canonical SUR2A/B surface complexes.

file:human/ABCC9/ABCC9-deep-research-falcon.md

Falcon deep research report for human ABCC9

Independent research synthesis describes SUR2 as a regulatory KATP subunit; primary literature was checked for all review decisions.