Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
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Established that C. elegans requires ire-1-mediated splicing of xbp-1 for UPR gene transcription
"C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress"
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Demonstrated that ire-1/xbp-1 and pek-1 act in complementary pathways essential for development
"ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival"
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hsp-4 identified as a UPR target gene
"C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress"
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response.
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Genome-wide survey showing hsp-4 (BiP) is robustly induced during UPR in xbp-1-dependent manner
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Established hsp-4::gfp as a standard ER stress reporter
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Demonstrated genetic interactions between UPR components and ERAD genes
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.
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Demonstrated that hsp-4 induction is specific to ER stress, not mitochondrial stress
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Established compartment-specific UPR signaling
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.
The unfolded protein response is required for dendrite morphogenesis.
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Demonstrated HSP-4::GFP co-localizes with rough ER marker TRAM
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Showed that HSP-4 overexpression rescues dendritic defects in ire-1 mutants
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Established HSP-4's role in protein folding capacity for dendrite development
Functionally diversified Caenorhabditis elegans BiP orthologs control body growth, reproduction, stress resistance, aging, and autophagy
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Demonstrated functional diversification between HSP-3 and HSP-4
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HSP-4 specialized for interorganellar signaling and ER-stress mitigation
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HSP-4 regulates ER-phagy via Sec-62 (C18E9.2) and crosstalk with IRE-1
Endoplasmic reticulum unfolded protein response transcriptional targets of xbp-1s mediate rescue from tauopathy
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hsp-4 identified among 116 XBP-1s upregulated genes
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HSP-4 upregulation partially rescues tauopathy
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ATF-6 required alongside IRE-1/XBP-1 for full neuroprotection
The unfolded protein response of the endoplasmic reticulum protects Caenorhabditis elegans against DNA damage caused by stalled replication forks
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DNA primase depletion induces germline hsp-4 expression
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hsp-4 induction can be ATF-6 dependent and partly IRE-1/XBP-1 independent
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Demonstrated context-dependent UPR branch requirements