AraC/XylS-family master activator of the P. aeruginosa type III secretion system.
Purified ExsA binds T3SS promoters PMID:18373522 and its C-terminal domain activates transcription PMID:19376850. It is held inactive by ExsD PMID:20008065. ExsA is required for (activates) the pathway PMID:1655713.
Other seeds from .cache/paint/IBD.gaf, 2026-11-05.
| PTN node | node term | n_seeds | leaf IBAs | seed annotation (term, evidence, PMID) | verdict | rationale | other seeds | IBD stands without this seed? |
|---|---|---|---|---|---|---|---|---|
| PTN002457187 | GO:0006355 regulation of DNA-templated transcription | 10 | 166 (24 taxa) | GO:0006355, IDA PMID:7635828 (PseudoCAP) | SOUND | Purified ExsA binds its promoters and activates transcription. Term correct, under-specific for ExsA (GO:2000144 is supported). Generic regulation suits the broad AraC/XylS clade. | E. coli AraC (P0A9E0), MelR, RhaS, ChbR, AdiY, GadW, YdeO, AppY, RclR; Yersinia LcrF (P28808) - all with experimental annotations | Yes |
Node term is generic transcriptional regulation and suits a 24-taxon AraC clade. No
PSEUDOCAP or GO_CENTRAL defect on the GO:0006355 seed; the leaf row is marked
TOO_GENERAL because GO:2000144 (CACAO IDA) entails it.
Other rows:
- GO:0050709 negative regulation of protein secretion IMP (PMID:1655713): WRONG term for
a transcriptional activator. ExsA regulates transcription of the secretion genes, not
secretion; and the sign is inverted (ExsA activates). REMOVE + PSEUDOCAP WRONG_TERM
(PROBABLE; 1655713 full text not read).
- GO:0005515 protein binding IPI (ExsD, PMID:20008065): REMOVE per protein-binding policy;
the ExsA-ExsD anti-activation is the informative content.
- GO:0003700, GO:0043565: TOO_GENERAL (entailed by GO:0001216 and GO:0000976).