Aminoglycoside antibiotics induce bacterial biofilm formation.
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arr is essential for aminoglycoside-induced biofilm formation and contributes to biofilm-specific aminoglycoside resistance.
"was essential for this induction and contributed to biofilm-specific aminoglycoside resistance"
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Membranes from arr mutants have less c-di-GMP phosphodiesterase activity.
"membranes from arr mutants had diminished c-di-GMP phosphodiesterase activity"
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
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Lysates of a PA14 strain overexpressing PA2818 showed no detectable c-di-GMP hydrolysis (Table 1, read in PMC full text); PA2818 is absent from most strains.
"Although the majority of these genes are components of the P. aeruginosa core genome, several are located on presumptive horizontally acquired genomic islands."
Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes.
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Deletion of PA2818 disrupts mushroom-like structures in flow-cell biofilms.
"deletion of PA2133 (fcsR; Rossello et al., 2017), PA2200 and PA2818 resulted in the disruption of mushroom-like biofilm structures"
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt