Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.
CAML is required for efficient EGF receptor recycling.
Immediate early gene X-1 interacts with proteins that modulate apoptosis.
Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.
Defining the membrane proteome of NK cells.
RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.
Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
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CAML is the mammal-specific TRC40 receptor that, with WRB, mediates insertion of tail-anchored proteins into the ER membrane.
"We identify calcium-modulating cyclophilin ligand (CAML) as a mammal-specific receptor for TRC40, an ATPase targeting newly synthesized TA proteins, and show that CAML mediates membrane insertion of TA proteins."
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
A proteome-scale map of the human interactome network.
Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR.
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In vitro reconstitution shows CAML and WRB together are sufficient to confer tail-anchored protein insertion competence to liposomes.
"in vitro synthesized CAML and WRB together were sufficient to confer insertion competence to liposomes"
Architecture of the human interactome defines protein communities and disease networks.
The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.
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CAML is integrated into the ER membrane with three C-terminal transmembrane segments, dependent on WRB for correct topology.
"is inserted into the ER membrane with three transmembrane segments (TMs) in its C-terminal region"
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.
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WRB and CAML reciprocally regulate each other's folding/stability within the insertase.
"When present, WRB can correct the topology of CAML both in vitro and in cells."
A reference map of the human binary protein interactome.
Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
CAMLG UniProtKB record (P49069)
Manual CAMLG curation notes