Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.
Development of glomerular endothelial cells, podocytes and mesangial cells in the human fetus and infant.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.
IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro.
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Cis-Heterodimerization of nephrin and KIRREL
Nephrin trans-homophilic interaction
Nephrin interacts with Podocin
Phosphorylation of nephrin by FYN
Interaction of IQGAP1 with nephrin
Heterodimerization of nephrin and KIRREL2, KIRREL3
Nephrin mediated activation of N-WASP
Nephrin dimer:KIRREL binds FYN
Nephrin is specifically located at the slit diaphragm of glomerular podocytes.
Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney.
Nephrin localizes to the slit pore of the glomerular epithelial cell.
The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.
Interaction with podocin facilitates nephrin signaling.
Nephrin promotes cell-cell adhesion through homophilic interactions.
Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.
A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.
Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.
UniProt entry O60500 (NPHN_HUMAN)