MSI1 curation notes

Session 2026-10-06 (vernalization_flc_silencing module follow-up)

• O22467, At5g58230; a p55/RbAp48 WD40 histone-binding protein.
• In all plant PRC2 complexes: PMID:23778966; links LHP1: PMID:23778966.
• CAF-1: PMID:17021044
• DREAM: PMID:34583930.
• MET1 repression with RBR1: PMID:18700816

Decisions

• negative regulation of transcription by RNA polymerase III (MET1 repression) -> MODIFY to RNA polymerase II, because MET1 is a Pol II gene.
• protein-containing complex (MEA/FIE 600 kDa) -> MODIFY to ESC/E(Z) complex.
• MSI1-LHP1 protein binding -> MODIFY to protein-macromolecule adaptor activity; other protein-binding rows -> REMOVE.
• CAF-1, DREAM and CUL4 roles plus developmental phenotypes -> KEEP_AS_NON_CORE. NEW: ESC/E(Z) complex, CAF-1 complex (TAS) and GO:0045814.