Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

Combined Automated Annotation using Multiple IEA Methods.

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.

Comparison of interleukin-22 and interleukin-10 soluble receptor complexes.

Structure of IL-22 bound to its high-affinity IL-22R1 chain.

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.

Structure and mechanism of receptor sharing by the IL-10R2 common chain.

IL22 binds IL22RA1:JAK1 receptor complex

IL22RA2 binds IL22

IL22:IL22RA1:JAK1 binds IL10RB:TYK2

IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3

IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2

IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3

IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11

p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3

IL22 Deep Research Report (AI-generated synthesis)