Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Combined Automated Annotation using Multiple IEA Methods

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Architecture of the human interactome defines protein communities and disease networks.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Mutational hotspot in the human biotinidase gene causes profound biotinidase deficiency.

Biotin transport and metabolism

Extracellular BTD hydrolyses BCTN

Defective extracellular BTD does not hydrolyse BCTN

Mitochondrial BTD hydrolyses BCTN

Defective mitochondrial BTD does not hydrolyse BCTN

UniProtKB entry P43251 (BTD_HUMAN)

Human serum biotinidase. cDNA cloning, sequence, and characterization.

Arg538 to Cys mutation in a CpG dinucleotide of the human biotinidase gene is the second most common cause of profound biotinidase deficiency in symptomatic children.

Partial biotinidase deficiency is usually due to the D444H mutation in the biotinidase gene.

Evolutionary conservation of biotinidase: implications for the enzyme's structure and subcellular localization.

Identification of alternatively spliced human biotinidase mRNAs and putative localization of endogenous biotinidase.