ERG8 (YMR220W) notes

UniProt P24521; phosphomevalonate kinase, EC 2.7.4.2; GHMP-type (fungal/plant) PMK, unrelated to animal PMVK [UniProt:P24521].

Evidence journal

• PMID:1846667
• Essential PMID:1846667; GAL1-ERG8 raises PMK activity 1000-fold; soluble 48 kDa protein.
• PMID:200835.
• C-terminus ...ETYLDK: no PTS1 [UniProt:P24521 sequence].

Decisions

• Vacuole NAS (Hu et al. 2017 review) REMOVE: unsupported, contradicts GFP/soluble data.
• Peroxisome IBA (plant node PTN000781523, Arabidopsis AT1G31910 only) REMOVE: plant PTS1-bearing PMK; yeast Erg8 lacks PTS1 and is cytoplasmic.
• ATP binding, nucleus HDA KEEP_AS_NON_CORE. Rest ACCEPT.