Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.
p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase.
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.
A nucleolar protein RRS1 contributes to chromosome congression.
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint.
Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition.
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers.
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint.
Toward an understanding of the protein interaction network of the human liver.
Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction.
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Molecular basis of APC/C regulation by the spindle assembly checkpoint.
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting microtubule dynamics and Wnt/β-catenin/EMT signaling in human colorectal cancer cells.
Multimodal cell maps as a foundation for structural and functional genomics.
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.
Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.
MAD2 converted to an inhibitory state via interaction with Mad1
Binding of the MCC complex to the APC/C complex
MAD2 associates with the Mad1 kinetochore complex
Formation of the MCC complex
Release of activated MAD2 from kinetochores
Phosphorylation of cohesin by PLK1 at centromeres
PP2A-B56 dephosphorylates centromeric cohesin
Ubiquitination of Cyclin A by APC/C:Cdc20 complex
Association of Cyclin A with the APC/C
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
Degradation multiubiquitinated Cyclin A
Association of Nek2A with MCC:APC/C
Multiubiquitination of Nek2A
Degradation of multiubiquitinated Nek2A
ESPL1 (Separase) cleaves centromeric cohesin
Separation of sister chromatids
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
Kinetochore capture of astral microtubules
CDC42:GTP recruits DIAPH2-2 to kinetochores
AURKB phosphorylates DIAPH2-2 at kinetochores
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
EML4 recruits NUDC to mitotic spindle
BUB1B deep research (falcon/Edison Scientific Literature)