KIF3B notes

Summary

• Motor subunit with intrinsic motor activity: PMID:7559760; heterodimer PMID:7559760
• Nodal cilia / L-R: PMID:9865700; PMID:9865700
• Human dominant ciliopathy: PMID:32386558; PMID:32386558
• Mitosis: PMID:16298999
• Neuronal: GRIN2A vesicle transport into dendrites (UniProt, by similarity to mouse).

Ciliary vs other roles

• Ciliary (core): motor activity, kinesin II, intraciliary transport (IMP), cilium assembly, IFT-B binding (IFT20), cilium/tip locations; NEW intraciliary anterograde transport (refines the existing intraciliary transport IMP).
• Ciliary but cell-type specific (non-core): opsin transport, left/right determination.
• Non-ciliary transport: plus-end vesicle transport, cytoskeleton-dependent transport (ACCEPT); axonal, dendritic and synaptic terms (KEEP_AS_NON_CORE).
• Mitotic: spindle organization/assembly KEEP_AS_NON_CORE; mitotic centrosome separation UNDECIDED (not in the cached abstract).
• small GTPase binding (IPI, 19635168): REMOVE — the partner recorded in GOA is ARHGEF10, a RhoA GEF and not a small GTPase PMID:19635168
• 10 generic protein binding rows REMOVE; urinary exosome HDA MARK_AS_OVER_ANNOTATED.

HPA cilium atlas vs module role

• HPA v25: Primary cilium tip (Approved); main locations Flagellar centriole; Nucleoplasm; Primary cilium tip.
• Module: kinesin-2 subunit; plus-end-directed microtubule motor activity; anterograde IFT; axoneme.
• Assessment: consistent. Tip enrichment fits an anterograde motor that delivers trains to the tip, where kinesin-2 is released or diffuses back. The core-function location is ciliary tip rather than the module's axoneme; both are correct, and the tip is what HPA observes.

Deep research

See below.
Falcon deep research: the first run (600 s timeout, perplexity fallback unavailable) was stopped. The rerun with a 2400 s timeout was reported by the wrapper as a timeout ("Provider falcon timed out after 2400s"), but falcon still wrote a complete report (KIF3B-deep-research-falcon.md, duration 2284 s). Points used:
- [file:human/KIF3B/KIF3B-deep-research-falcon.md "In human hTERT-RPE1 cells, KIF3B knockout prevented cilium formation, while IFT-A and IFT-B components could still assemble and reach the mother centriole."] (Tasaki et al. 2025, not cached.) This supports KIF3B being required for ciliogenesis downstream of IFT assembly.
- Non-ciliary: Rab11-FIP5 binds the KIF3B tail, and KIF3B controls endosome positioning/transferrin receptor recycling (Schonteich 2008, as reported in the deep research). This is consistent with treating vesicle transport as a non-ciliary use of the motor.