TreeGrafter-generated GO annotations
Deep research report on TTC39C in Macaca fascicularis
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
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ttc39c knockdown reduces Kupffer's vesicle cilia number and length in zebrafish.
"We thus examined KV cilia in embryos at the 7-somite stage and found that both the number and length of the KV cilia were significantly reduced in the ttc morphants"
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ttc39c morphant pronephric cilia are largely paralysed.
"Strikingly, many cilia were paralyzed in the ttc9c, ttc36, and ttc39c morphants"
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TTC39C subcellular localization could not be determined.
"As to TTC39c, we were not sure of its subcellular localization because the antibody did not work for immunostaining."
A0A2K5UJ34 sequence identity re-review
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A0A2K5UJ34 corresponds to human TTC39C residues 39-583 with 2 substitutions; it lacks the disordered N-terminal 38 residues but retains all annotated TPR repeats.
"Ungapped identity over the 545 aligned residues is 0.9963"
PAINT IBD assertions for PANTHER family PTHR31859
UniProt record A0A2K5UJ34