Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Functional proteomics mapping of a human signaling pathway.
The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.
Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
miR-126 regulates angiogenic signaling and vascular integrity.
Docking motif-guided mapping of the interactome of protein phosphatase-1.
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
A directed protein interaction network for investigating intracellular signal transduction.
Protein phosphatase 1α interacting proteins in the human brain.
Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity.
MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells.
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
RAS GAPs stimulate RAS GTPase activity
KBTBD7:CUL3:RBX1 ubiquitinates NF1
NF1 is degraded by the proteasome
Loss-of-function NF1 variants don't stimulate RAS GTPase activity
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation.
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Spred is a Sprouty-related suppressor of Ras signalling.
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.
Distinct requirements for the Sprouty domain for functional activity of Spred proteins.
SPRED proteins and their roles in signal transduction, development, and malignancy.
Falcon deep research report on SPRED1
SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling.