Vps26 (CG14804) notes

Retromer cargo-selective complex subunit (arrestin fold).

• Wls retrieval / Wg secretion PMID:18193032; Hh/Dpp unaffected (UniProt: "The hh and dpp signaling pathways do not require the retromer complex").
• Notch as retromer cargo in neuroblast lineages; model returns Notch to cell surface PMID:30176986.
• Fat body lysosome function PMID:26172538.
• iPLA2-VIA binds Vps26/Vps35 PMID:29909971.

Decisions: cargo receptor activity -> cargo adaptor activity (contributes_to; retromer is peripheral, not a TM receptor); obsolete endosome-to-PM transport -> endocytic recycling (GO replaced_by); retromer complex -> cargo-selective complex; protein binding -> phospholipase binding; regulation of Wnt signaling -> positive regulation of Wnt protein secretion.
Deep research: falcon completed (Vps26-deep-research-falcon.md) after the initial review; consistent with the review (non-enzymatic retromer cargo-sorting subunit). It adds fly epithelial cargo data not in GOA: Crumbs maintenance [file:DROME/Vps26/Vps26-deep-research-falcon.md "In wing discs, Vps26 RNAi reduced Crumbs fluorescence by approximately 50%, similar to Vps35 RNAi."] and Megatrachea delivery to septate junctions, plus neuronal maintenance downstream of Mtd/OXR1 (2024). No annotation actions changed.