Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Combined Automated Annotation using Multiple IEA Methods
ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner.
Intracellular localization of GASP/ECOP/VOPP1.
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VOPP1 has both a signal sequence and transmembrane domain
"Analysis of VOPP1 sequence structure shows both a signal sequence and a transmembrane domain"
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VOPP1 shows intracellular vesicular pattern of localization
"VOPP1 protein tagged with a fluorescence reporter, as well as antibody-mediated visualization of recombinant and native forms of the protein reveals an intracellular vesicular pattern of localization"
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VOPP1 vesicles show partial co-localization with perinuclear lysosomes
"Co-localization experiments reveal that VOPP1 vesicles do not co-localize with mitochondria or peroxisomes, but show partial co-localization with perinuclear lysosomes"
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VOPP1 protein is not secreted and is retained intracellularly
"Immunoblot analysis of cell culture and conditioned media confirms that the protein product is not secreted and is retained intracellularly"
VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX.
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VOPP1 interacts with WWOX via the WW domain recognizing PPPY motif
"We performed a yeast two-hybrid screen to identify new WWOX-interacting proteins"
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VOPP1 sequesters WWOX in lysosomes
"In breast cancer cells, VOPP1 sequestrates WWOX in lysosomes"
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VOPP1-WWOX complex resides in late endosomes/lysosomes
"Altogether, these results strongly indicated that the WWOX and VOPP1 complex resides in the late endosomes/lysosomes"
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VOPP1 inhibits WWOX-dependent apoptosis by preventing WWOX-p73alpha interaction
"VOPP1 sequestrates WWOX in lysosomes, impairs its ability to associate with p73alpha, and inhibits WWOX-dependent apoptosis"
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VOPP1 has transforming activity and induces tumorigenic phenotype
"Collectively, these results indicated that VOPP1 had transforming activity and induced a tumorigenic phenotype"
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
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High-throughput AP-MS interactome study (BioPlex 3.0)
"Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks"
Deep research report on VOPP1
Cyberian deep research on VOPP1 function