Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfolded polypeptides.
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Recombinant C. elegans HSP16-2 suppresses thermally induced aggregation of citrate synthase and binds early unfolding intermediates of actin and tubulin.
"both wild-type and C-terminally-truncated HSP16-2 can function as molecular chaperones by suppressing the thermally-induced aggregation of citrate synthase"
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Association of several small heat-shock proteins with reproductive tissues in the nematode Caenorhabditis elegans.
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Immunohistochemical localization of HSP16s to vulva, spermatheca, and reproductive tissues
"Immunohistochemical data on 10 of the 14 small heat-shock (smHSPs) proteins in fourth larval stage and adult Caenorhabditis elegans show that the tissues expressing the greatest number of smHSPs are vulva (HSP12s, HSP43 and, under stress, HSP16s) and spermatheca (HSP12s, HSP25, HSP43 and, under stress, HSP16s)"
Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans.
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hsp16-lacZ transgene expression is totally heat-shock dependent
"Transcription of the hsp16-lacZ transgenes was totally heat-shock dependent and resulted in the rapid synthesis of detectable levels of beta-galactosidase"
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Differential tissue expression patterns between hsp16 gene pairs
"Although the two hsp16 gene pairs of C. elegans are highly similar within both their coding and noncoding sequences, quantitative and qualitative differences in the spatial pattern of expression between gene pairs were observed"
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hsp16 genes are not heat-inducible during gametogenesis or early embryogenesis
"Although the hsp16 gene pairs are never constitutively expressed, their heat inducibility is developmentally restricted; they are not heat inducible during gametogenesis or early embryogenesis"
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.
Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.
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Describes structure of hsp16-2/41 locus with divergently transcribed gene pair
"A locus containing two hsp16 genes in Caenorhabditis elegans has been characterized by DNA sequencing"
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Each gene encodes a 16-kDa polypeptide expressed following heat induction
"Each gene encodes a 16-kDa polypeptide which is expressed following heat induction"
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Family consists of four related small heat shock protein genes
"the results presented here define a family of four distinct, related small heat shock protein genes"
Visible light reduces C. elegans longevity.
Deep research report on hsp-16.2