Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Identification and characterization of AFG3L2, a novel paraplegin-related gene.

Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia.

An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases.

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.

Proteolytic control of the mitochondrial calcium uniporter complex.

m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.

Dissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease.

Mitochondrial stress response triggered by defects in protein synthesis quality control.

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Regulation of mitochondrial proteostasis by the proton gradient.

Autoregulatory control of mitochondrial glutathione homeostasis.

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.

SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis.

PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)

AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU

C2orf47:AFG3L2 binds the transit peptide of SMDT1

AFG3L2 binds mitochondrial inner membrane proteins

AFG3L2:SPG7 binds SMDT1 (EMRE)

AFG3L2:SPG7 degrades SMDT1 (EMRE)

AFG3L2 degrades mitochondrial matrix proteins

AFG3L2 degrades mitochondrial inner membrane proteins

AFG3L2 binds mitochondrial matrix proteins

UniProtKB record for human AFG3L2 (Q9Y4W6)

Falcon deep research report for human AFG3L2

AFG3L2 curator notes for Proteostasis PN review

Proteostasis Network projected GO annotations report

Proteostasis Network mitochondrial proteostasis mapping

Autocatalytic processing of m-AAA protease subunits in mitochondria.

Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation.

Molecular Determinants of Mitochondrial Shape and Function and Their Role in Glaucoma.

Sustained OMA1-mediated integrated stress response is beneficial for spastic ataxia type 5.

Multifaceted Roles of AFG3L2, a Mitochondrial ATPase in Relation to Neurological Disorders.

Autosomal recessive cerebellar ataxias: a diagnostic classification approach according to ocular features.