PAH1 (YMR165C, P32567) notes

Evidence journal (UniProt and cached publications; no paid deep research).

• Pah1 is the yeast lipin and the Mg2+-dependent PAP. PMID:16467296
• It is essential for TAG synthesis among the four PAP genes. PMID:24196957
• Pah1 is inactive in the cytosol and active on the membrane. PMID:35026226
• The catalytic DXDXT motif is required for all of its physiological roles. PMID:17971454
• Pleiotropic phenotypes: lipid droplet number, vacuole fusion, respiration, and plasmid stability. PMID:21422231 PMID:22121197 PMID:8437575
• Curation decisions: PAP activity, DAG and TAG biosynthesis, and the nuclear/ER membrane are core. The promoter ChIP-based "cis-regulatory region binding" and the IBA "fatty acid catabolic process" (a mammalian PPARalpha-coactivator role) are marked over-annotated. The RCA "is_active_in cytosol" row is modified to ER membrane. LD organisation, vacuole fusion, respiration and plasmid maintenance are non-core.