Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes.
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands.
Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity.
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
Calcium-regulated intramembrane proteolysis of the RAGE receptor.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells.
The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
Tumor-associated MICA is shed by ADAM proteases.
Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury.
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.
Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes.
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells.
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10.
TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.
Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.
A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity.
Visualization of Alzheimer's Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer.
TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cholesterol sensing by CD81 is important for hepatitis C virus entry.
GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site.
Multimodal cell maps as a foundation for structural and functional genomics.
Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types.
Degradation of the extracellular matrix
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
E-cadherin degradation by ADAM10, ADAM15
Exocytosis of tertiary granule membrane proteins
Exocytosis of specific granule membrane proteins
FAM20C phosphorylates FAM20C substrates
ADAM10:Zn2+:TSPANs cleaves APP(18-770)
ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane
NOTCH3-ligand complex is cleaved to produce NEXT3