Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
A reference map of the human binary protein interactome.
CYB5D2 requires heme-binding to regulate HeLa cell growth and confer survival from chemotherapeutic agents.
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D86 is critical for heme binding
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CYB5D2 localizes to ER and colocalizes with CYPOR
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Knockdown reduces CYP51A1 and CYP3A4 activity
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CYB5D2 suppresses cell proliferation and anchorage-independent growth
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CYB5D2 confers chemotherapeutic resistance through heme-dependent mechanisms
Membrane associated progesterone receptors promiscuous proteins with pleiotropic functions - focus on interactions with cytochromes P450.
Deep research summary for CYB5D2