Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
ATM-dependent phosphorylation of nibrin in response to radiation exposure.
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.
-
ATM phosphorylates the Pin2/TRF1 protein substrate.
"activated ATM
directly phosphorylated Pin2/TRF1 preferentially on the conserved Ser(219)-Gln
site in vitro and in vivo."
-
Replace generic binding with the protein kinase activity supported by the same source.
"directly phosphorylated Pin2/TRF1 preferentially on the conserved Ser(219)-Gln"
Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
A new effector pathway links ATM kinase with the DNA damage response.
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Involvement of novel autophosphorylation sites in ATM activation.
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
-
Accept ATM participation in the mitotic G2 DNA-damage checkpoint, while preserving the source-specific reading limit.
"the maintenance of the G2/M checkpoint induced by DNA damage."
ATMIN defines an NBS1-independent pathway of ATM signalling.
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Tel2 regulates the stability of PI3K-related protein kinases.
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
A role for DEAD box 1 at DNA double-strand breaks.
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.
USP10 regulates p53 localization and stability by deubiquitinating p53.
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
The histone demethylase LSD1/KDM1A promotes the DNA damage response.
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
Systematic identification of molecular links between core and candidate genes in breast cancer.
Notch is a direct negative regulator of the DNA-damage response.
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
-
Accept the experimentally supported ATM-dependent response to X-rays.
"phosphorylation of NUCKS1 at Ser54 was dependent on ATM, independent of DNA-PK"
ATM functions at the peroxisome to induce pexophagy in response to ROS.
ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells.
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres.
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Molecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-Telangiectasia.
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study.
Structures of closed and open conformations of dimeric human ATM.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors.
UFL1 promotes histone H4 ufmylation and ATM activation.
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks.
A reference map of the human binary protein interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.
Metabolic regulation of homologous recombination repair by MRE11 lactylation.
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
ATM gene product phosphorylates I kappa B-alpha.
-
The reported ATM immunoprecipitate assay did not detect phosphatidylinositol kinase activity under its conditions.
"we did not observe a
phosphatidyl-3 kinase or a DNA-dependent protein kinase function by ATM
immunoprecipitates."
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.
-
Human ATM is predominantly nuclear, with cell-dependent extranuclear fractions.
"predominantly confined to the nucleus of human fibroblasts"
Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms.
Interaction between ATM protein and c-Abl in response to DNA damage.
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
ATM associates with and phosphorylates p53: mapping the region of interaction.
A role for ATR in the DNA damage-induced phosphorylation of p53.
Regulation of HSF1-mediated heat shock response
DBC1 is phosphorylated by ATM/ART
Phosphorylation of COP1 at Ser-387 by ATM
Phosphorylation of MDM4 by ATM
TP53 Regulates Transcription of Cell Death Genes
MRN complex bound to shortened telomeres recruits ATM
MRN bound to shortened telomeres activates ATM
KAT5 acetylates ATM at DNA DSBs
HERC2 and PIAS4 are recruited to DNA DSBs
RNF8 binds phosphorylated MDC1 at DNA DSBs
PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
RNF8 and RNF168 ubiquitinate H2AFX
WHSC1 dimethylates histone H4 on lysine K21 at DSBs
RNF8 and RNF168 ubiquitinate KDM4A,B
UIMC1 and FAM175A bind DNA DSBs
Formation of BRCA1-A complex at DNA DSBs
PPP5C dephosphorylates TP53BP1
ATM phosphorylates TP53BP1 at DNA DSBs
CHEK2 is recruited to DNA DSBs
CHEK2 phosphorylates BRCA1
ATM phosphorylates EYA1-4
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
APBB1 and MAPK8 bind diphosphorylated H2AFX
MRN complex binds CDK2 and RBBP8
CDK2 phosphorylates RBBP8
BRCA1 binds phosphorylated RBBP8
Binding of ATR:ATRIP to RPA at resected DNA DSBs
CHEK1 is recruited to resected DNA DSBs
Activation of CHEK1 at resected DNA DSBs
ATR activation at DNA DSBs
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
Long-range resection of DNA DSBs by EXO1 or DNA2
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Activated ATM phosphorylates ABL1
RAD52 promotes single strand annealing at resected DNA DSBs
ERCC1:XPF cleaves flaps generated by SSA
RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
Activated ATM phosphorylates DCLRE1C
TP53BP1 recruits DCLRE1C to ATM
Ligation of DNA and formation of Holliday structures following repair synthesis
Association of RPA complexes with ssDNA at resected DNA DSBs
ATM phosphorylates histone H2AFX on S139 at DNA DSBs
Phosphorylation of BRCA1-A complex at multiple sites by ATM
RAD51 binds BRCA2 at resected DNA DSBs
Association of RAD51 with RAD52:DNA double-strand break ends
TP53BP1 associates with H4K20Me2 at DNA DSBs
Nonhomologous End-Joining (NHEJ)
Association of RAD52 with the RPA complex at resected DNA DSBs
MDC1 associates with gamma-H2AFX at nuclear foci
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
Association of Ku heterodimer with ends of DNA double-strand break
ATM recognizes H2AFX-Nucleosomes
DNA Double Strand Break Response
Initial resection of double-strand break ends
ATM phosphorylates TP53 at S15
MRN complex bound to DNA ends recruits ATM
D-loop formation mediated by PALB2, BRCA2 and RAD51
KAT5 acetylates ATM at shortened telomeres
ATM phosphorylates ZNF420
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Activity through Methylation
Regulation of TP53 Expression and Degradation
p53-Dependent G1 DNA Damage Response
Phosphorylation and activation of CHEK2 by ATM
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
ATM dimer:PEX5 phosphorylates PEX5
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
NBR1 binds ATM:Ub-p-PEX5:SQSTM1
ATM:PEX5 translocates from cytosol to peroxisomal membrane
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
SQSTM1 binds ATM dimer:Ub-p-PEX5
USP30 deubiquitinates ATM dimer:Ub-p-PEX5
USP30 binds ATM dimer:Ub-p-PEX5
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA