Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A visual intracellular classification strategy for uncharacterized human proteins.
Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.
A proteome-scale map of the human interactome network.
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
A mitochondrial iron-responsive pathway regulated by DELE1.
The HRI branch of the integrated stress response selectively triggers mitophagy.
DELE1(143-515) is released into the cytosol
DELE1(143-515) binds EIF2AK1 (HRI)
DELE1 oligomerization promotes integrated stress response activation.