Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10479480

Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein.

Human hVLCS-H2 (SLC27A5) is liver-specific, ER-associated, and activates long-chain and very-long-chain fatty acids (C18:0-C26:0) to their CoA thioesters.

PMID:10749848

The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase.

hVLCS-H2 (SLC27A5) is cholate ligase; unconjugated bile acids must be activated to CoA thioesters before glycine/taurine conjugation, and the enzyme is proposed to re-activate/re-conjugate bile acids from the enterohepatic circulation.

PMID:11980911

Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling.

SLC27A5 activates chenodeoxycholate, deoxycholate, lithocholate and the C27 precursor THCA in addition to cholate; its primary function is proposed to be reactivation and recycling of C24 bile acids.

PMID:20530735

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase.

FATP family members act as plasma-membrane-associated LCFA transporters and acyl-CoA synthetases in liver; used here to contextualize FATP5's fatty-acid uptake/transport role.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI proteome-scale binary interactome; source of the single high-throughput SLC27A5-MEOX2 interaction underlying the protein binding IPI annotation.

Reactome:R-HSA-159418

Recycling of bile acids and salts

Reactome:R-HSA-159425

Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)

Reactome:R-HSA-192137

THCA is conjugated with Coenzyme A (SLC27A5 BACS)

Reactome:R-HSA-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Reactome:R-HSA-193407

DHCA is conjugated with Coenzyme A (SLC27A5 BACS)

Reactome:R-HSA-193711

3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)

Reactome:R-HSA-193766

Bile-acyl-CoA conjugation reaction (SLC27A5 BACS)

Reactome:R-HSA-193775

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

file:human/SLC27A5/SLC27A5-uniprot.txt

UniProtKB Q9Y2P5 (SLC27A5 / S27A5_HUMAN) entry

UniProt describes SLC27A5 as bile acyl-CoA synthetase (EC 6.2.1.7) that mainly activates bile acids to their CoA thioesters prior to conjugation, also with LCFA/VLCFA-CoA ligase activity (EC 6.2.1.3), localized to the endoplasmic reticulum membrane as a multi-pass membrane protein.