PA2634 (aceA, Q9I0K4) notes

Literature

No deep-research provider was available. PubMed search via the MCP returned an API error on 2026-11-05;
the review rests on the cached abstract of PMID:17319879, the cached full text of PMID:23363478 and the
reviewed UniProt entry (structure PDB 6G1O).

PA2634 is aceA, the sole ICL PMID:17319879.
Activity in crude extracts, induced by acetate, citronellol, leucine PMID:17319879; complementation PMID:17319879.
Biofilm phenotype is shared with other TCA/glyoxylate mutants PMID:23363478.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN000493043	GO:0004451 isocitrate lyase activity	9	102 (75 taxa)	GO:0004451, IDA, PMID:17319879 (PseudoCAP)	SOUND	Abstract: ICL activity in wild-type extracts plus a complemented aceA mutant; full ICL signature. Strictly an IMP+IDA combination, not a purified-enzyme assay.	E. coli AceA P0A9G6, M. tuberculosis P9WKK7 and O07718, yeast SGD:S000000867, Candida CGD:CAL0000178151, Arabidopsis AT3G21720, rice Q6Z6M4, Q6T267	Yes. Characterised ICLs from bacteria, fungi and plants; the term suits the ICL clade.

No PSEUDOCAP or GO_CENTRAL defect.

Other decisions

GO:1900232 negative regulation of biofilm formation (PseudoCAP IMP, PMID:23363478, full text read):
MARK_AS_OVER_ANNOTATED. Indirect metabolic phenotype shared by aceE, aceK, icd-idh and glcB mutants.
No defect recorded (not a seed).
GO:0003824: TOO_GENERAL.