Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat.
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.
Defining the membrane proteome of NK cells.
Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses.
ANKRD17 primary-source, ontology and access-scope notes
Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.
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Overexpressed human Mask2/ANKRD17 stabilizes YAP abundance in Caco2 cells. The separate large-droplet HEK293T experiment used Mask1/ANKHD1 and is not assigned to ANKRD17.
"We find that overexpression of either Mask1 or Mask2 caused strong stabilisation of YAP protein levels in Caco2 cells (Figure 6A,B)."
Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism.
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A human cohort of 34 individuals from 32 families with heterozygous ANKRD17 variants supports haploinsufficiency as the mechanism of a neurodevelopmental syndrome; these clinical data do not identify a direct developmental molecular step.
"The mutational spectrum of this
cohort of 34 individuals from 32 families is highly suggestive of
haploinsufficiency as the underlying mechanism of disease"
Novel ANKRD17 variants implicate synaptic and mitochondrial disruptions in intellectual disability and autism spectrum disorder.
ANKRD17 induces pro-survival signaling pathways that enhance cellular invasion and migration during hepatocellular carcinoma tumorigenesis.
Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis.