Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:10814712

A novel protein with RNA-binding motifs interacts with ataxin-2.

A2BP1/RBFOX1 is an ATXN2-interacting RNA-binding protein; the RNA-recognition motif described for that partner is not an ATXN2 domain.
The Discussion proposes a possible neuronal RNA-transport role; the reported experiments do not measure RNA-cargo movement. This is a hypothesis rather than direct transport evidence.

PMID:10973246

Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human.

PMID:12812977

Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death.

PMID:15663938

An integrative approach to gain insights into the cellular function of human ataxin-2.

PMID:16115810

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.

PMID:16713569

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

PMID:16835262

Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes.

Human ataxin-2 and fly ATX2 associate with polyribosomes. Association supports an RNA-regulatory context but does not by itself measure translation activation. The general RNP-complex class is supported; fly region mapping is not assigned to human isoforms or used to call ATXN2 a constitutive ribosomal structural subunit.

PMID:17097639

Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death.

Parkin ubiquitinates normal and expanded ataxin-2; ATXN2 is the substrate rather than the ubiquitin-ligase catalyst.

PMID:17392519

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.

Human ATXN2 associates with DDX6, redistributes to stress granules and alters granule properties following depletion. Elevated ATXN2 disrupts visible P-bodies, whereas depletion lacks an obvious P-body effect in the tested conditions.

PMID:18602463

Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.

The abstract reports ER/plasma-membrane association in transfected cell lines, supplemented by mouse-brain fractionation and a conserved pattern in rat hippocampal neurons. This corroborates membrane association without resolving the original HDA target table.

PMID:19946888

Defining the membrane proteome of NK cells.

PMID:20181956

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.

Structural analysis establishes recognition of an ataxin-2 PAM2 segment by the PABPC MLLE domain, supporting a defined protein interface rather than an intrinsic polymerase activity.

PMID:20740007

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.

PMID:22658674

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

PMID:22681889

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

PMID:23209657

Ataxin-2-like is a regulator of stress granules and processing bodies.

Although centered on ATXN2L, the original study also assays ATXN2 association with G3BP in Figure 4B. Its title alone does not establish a paralog misattribution.

PMID:24981860

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

PMID:26184334

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

PMID:39251607

Systematic identification of post-transcriptional regulatory modules.

PMID:24954906

Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.

PAR-CLIP identifies direct ATXN2 contacts enriched in U-rich mRNA 3′-UTR elements. Depletion, overexpression and tethering support target stabilization and increased protein abundance; RNA contact is distinguishable from PABPC1-mediated recruitment.

PMID:27240544

Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation.

The study links ataxin-2 to translation-initiation components and nutrient-responsive regulation. Mouse fibroblast deficiency and human neuroblastoma starvation experiments are separate endpoints; the tested knockout setting does not abolish stress-granule formation.

PMID:32989052

Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation.

Human ATXN2 increases reporter translation efficiency and heavy-polysome association, and recruits PABPC1 and TENT2/PAPD4 to promote cytoplasmic polyadenylation. Partial PAPD4 depletion diminishes the tail-extension effect. The polymerase reaction is performed by TENT2, not ATXN2.

PMID:37295429

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

Human ATXN2-knockout HeLa cells retain arsenite-induced stress granules with altered size and number. PAM2-dependent PABPC interactions control partitioning and condensation; PABPC acts as the RNA-dependent chaperone and ATXN2 as its regulated client.

PMID:38869059

Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules.

Human-cell perturbations link poly(A)-tail length and PABPC1 interactions to stress-granule formation. ATXN2 depletion reduces granule formation under the tested conditions, and full-length rescue outperforms a C-terminal truncation; dominant-negative PAM2 experiments are a separate endpoint.