Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins.
-
Zebrafish expresses two tropoelastin genes that share the characteristic tropoelastin domain arrangement and crosslinking motifs.
"Unlike other species, two tropoelastin genes were expressed in zebrafish."
Differential expression of two tropoelastin genes in zebrafish.
-
Both tropoelastins are expressed in most elastic tissues; eln2 (elnb) predominates in the bulbus arteriosus.
"with the notable exception of the bulbus arteriosus in which eln2 expression and its gene product was predominant"
Comparative genomics of elastin: Sequence analysis of a highly repetitive protein.
Evolution of the fish heart by sub/neofunctionalization of an elastin gene.
-
elna and elnb arose by duplication after the split from gar, with limk1a/limk1b neighbours supporting duplication of the locus in the TGD.
"Taken together, these results indicate that genomic locus including eln and limk1 genes was duplicated in the 3R WGD."
-
elna is broadly expressed, like the single Polypterus eln.
"As expected, Polypterus had one elastin gene, and its expression was observed in various tissues including OFT, which is similar to that of zebrafish elna"
-
elna morphants have a swim bladder defect but no bulbus arteriosus morphology defect.
"elna morphants exhibited a swim bladder defect, where elna expression level is relatively high"
-
elna mRNA cannot rescue the elnb morphant bulbus phenotype.
"injection of elnb MO and elna full-length mRNA did not rescue the elnb morphant phenotype"
Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies.
-
Elna is closer to human ELN (about 37% identity) than Elnb is (about 18%).
"They share approximately 37% identity and 41% similarity, whereas for Elnb, around 18% identity and 21% similarity were calculated."
Characterization of the Zebrafish Elastin a (elna(sa12235)) Mutant: A New Model of Elastinopathy Leading to Heart Valve Defects.
-
elna nonsense mutants have reduced valve elastin and shortened lifespan, but normal embryonic survival.
"Heterozygous (elnasa12235/+) and homozygous (elnasa12235/sa12235) mutants were found to have a significantly decreased life expectancy compared with their wild-type siblings."
Duplication, Divergence and Cardiac Expression of Tropoelastin in Jawed Fishes, Including Tetraploid Rainbow Trout (Oncorhynchus mykiss).
-
Non-teleost fishes have a single eln gene; teleosts have elna and elnb in a conserved eln-septin4/5-limk1 syntenic block.
"All non-teleost genomes contain a single eln gene, whereas duplicated elna and elnb genes were found in teleosts"
Deep research report for elna (Falcon)