Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner.
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
The protein network of HIV budding.
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
Identification and proteomic profiling of exosomes in human urine.
Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.
The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants.
The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis.
ALIX-CHMP4 interactions in the human ESCRT pathway.
Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release.
Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101.
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse.
Defining the membrane proteome of NK cells.
TEX14 interacts with CEP55 to block cell abscission.
Membrane budding and scission by the ESCRT machinery: it's all in the neck.
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.
Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.
A physical interaction network of dengue virus and human proteins.
Toward an understanding of the protein interaction network of the human liver.
Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B.
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix).
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
Protein interactions of the transcription factor Hoxa1.
Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.
Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles.
ESCRT requirements for EIAV budding.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.
A proteome-scale map of the human interactome network.
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Recruitment Of HIV Virion Budding Machinery
MLKL binds PDCD6IP and SDCBP
UniProtKB entry Q8WUM4 (PDCD6IP/ALIX)
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ALIX is a multifunctional ESCRT adaptor involved in MVB cargo sorting, exosome biogenesis, cytokinesis, and viral budding contexts.
"Adapter for a subset of ESCRT-III proteins, such as CHMP4"
PDCD6IP review notes
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PDCD6IP/ALIX core function is ESCRT adaptor activity, not undifferentiated protein binding.
"The core biological picture is not undifferentiated binding"