Ucp2 (rat) review notes

2026-10-26 - initial review

• Fetched with just fetch-gene rat Ucp2; UniProt P56500 confirmed. 102 GOA rows, most of them ISO/ISS/IEA
  transfers from human (P55851) and mouse (P70406) UCP2; rat experimental rows are IDA (PMID:12372827), IMP
  (PMID:18703058, PMID:21172424) and a set of IEP expression studies.
• Literature synthesis in Ucp2-deep-research-manual.md (no deep-research API available).
• Decisions follow the human UCP2 review for consistency across orthologues:
• Core: dicarboxylate:phosphate antiporter activity (GO:0015364) in the mitochondrial inner membrane;
  malate/oxaloacetate/aspartate transport terms accepted PMID:24395786.
• Proton transport, chloride, sulfate, phosphate uniport, fatty-acid transport, GDP binding: kept non-core.
• Oxidative phosphorylation uncoupler activity, response to cold, adaptive thermogenesis (IBA from UCP1 node):
  marked over-annotated.
• Expression-only IEP rows (lead, dexamethasone, liver regeneration, amino-acid starvation) marked
  over-annotated; nutrient/hormone response IEP rows kept non-core.
• PMID:18692019 (full text read): glutamine omission lowers UCP2 protein translationally PMID:18692019; the
  "cellular response to amino acid starvation" IEP was therefore judged over-annotation (UCP2 is regulated,
  not a participant).
• Negative regulation of calcium import into mitochondrion (from human IDA): UNDECIDED, as in human review.
• No NEW annotations proposed; nothing passed the participation bar beyond existing terms.