Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry Q03426 (KIME_HUMAN), Mevalonate kinase

Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome.

Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease.

Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.

Cholesterol biosynthesis is not defective in peroxisome biogenesis defective fibroblasts.

Mevalonate kinase is a cytosolic enzyme in humans.

Towards a proteome-scale map of the human protein-protein interaction network.

AA amyloidosis complicating hyperimmunoglobulinemia D with periodic fever syndrome: a report of two cases.

Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.

A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

Identification of catalytic residues in human mevalonate kinase.

Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.

Expression of Mevalonate Kinase (MVK)

Mevalonate is phosphorylated to mevalonate-5-phosphate